Category Archives: Biotechnical and medical systems

DECISION SUPPORT SYSTEM FOR DETERMINING THE DOSAGE OF MEDICATIONS IN THE TREATMENT TECHNOLOGY OF PREECLAMPSIA OF PREGNANT WOMEN


UDC 004.891
DOI:10.26102/2310-6018/2020.29.2.017

M.V. Grankov, I.A. Tarasova

The problem of preeclampsia is one of the urgent in modern obstetrics, since this disease is the most common and serious complication of pregnancy, and the problem of treating severe forms of preeclampsia is one of the most difficult in obstetric anesthesiology and resuscitation. The high mortality rate is based on the lack of accurate knowledge about the pathogenesis of the disease, which depends on many factors, diagnostic criteria, which leads to inadequate therapy and various complications, depending on the timeliness and method of delivery, the volume of anesthetic and resuscitation care. Therefore, the study of methods for constructing automated and expert systems using modern methods of artificial intelligence and allowing to increase the effectiveness of the treatment of preeclampsia of pregnant women is relevant. This article discusses the development of a decision support system for determining the dosage of medications in the treatment technology of preeclampsia of pregnant women based on membership functions of several arguments. As a result of experimental tests, it was found that the relative deviation of the dosages calculated by the decision support system from the dosages established in the comparative tests by a qualified doctor does not exceed five percent. At the same time, the use of the results of the work made it possible to increase the number of severe patients served by one resuscitation doctor by at least two times, by reducing the time to establish a diagnosis.

Keywords:decision support system, diagnostics, treatment technology, preeclampsia of pregnant women, membership function of several arguments.

Full text:
GrankovTarasova_2_20_1.pdf

MODIFICATION OF GENETIC ALGORITHM WITH ADAPTIVE CROSSOVER SWITCHING


UDC 681.3
DOI:10.26102/2310-6018/2020.29.2.009

Y.A. Asanov, S.Y. Beletskaya, Al-Saedi Mohanad Ridha Ganim

The aim of this work is to develop a modification of the adaptive genetic algorithm based on switching crossover in accordance with the degree of elitism of individuals in the population. Despite the enormous amount of research done in the field of evolutionary calculus in recent years, algorithms of this class today have a high prospect of modification. The main aim of research is carried out in order to improve the convergence rate of algorithms (to obtain high-performance optimization methods) and increase the accuracy of the solutions obtained. In the article, for the adaptive tuning of the crossover operator, the concepts of discrete and continuous degree of elitism of individuals are used. In addition, an elitism score is used to adjust the probability of a mutation. This modification has a serious advantage superiority in test problems which are traditionally used to analyze the efficiency of genetic algorithms. The test set used was a quadratic function with three variables, a Rosenbrock function, a step function, a complex fourth-order function with noise, and the Sheckel function. The results of comparing classical genetic algorithms with algorithms using the considered crossover and mutation tuning strategies are presented. An analysis of the results of a computational experiment is presented.

Keywords:genetic algorithm, switching crossover, adaptive mutation tuning, elitism, evolutionary calculus.

Full text:
AsanovSoavtors_2_20_1.pdf

APPLICATION OF CORRELATION ANALYSIS TO IDENTIFY FACTORS FROM A WOMAN’S ANAMNESIS INFLUENCING THE RESULTS OF PREGNANCY OBTAINED BY INF


UDC 519.234.3
DOI:10.26102/2310-6018/2020.28.1.027

S.L. Sinotova, O.V. Limanovskaja, A.N. Plaksina, V.A. Makutina

This article discusses the search for a statistical relationship between diseases of the genitourinary system, chronic diseases, surgical interventions and other data on the anamnesis, a woman’s heredity and pregnancy outcome obtained using assisted reproductive technologies (IVF). The study is conducted with the aim of developing a mathematical model for predicting pregnancy and assessing the health of a child conceived using ART (IVF) at the stage of planning. The conclusions are based on data on 338 women and the diagnoses of their 402 children at the stage of the maternity hospital. A research was made for the effect of 56 binary signs on the outcome of pregnancy, described by 38 characteristics. To identify significant factors, a correlation analysis was performed using Fisher’s exact test, Chi-square test, and using interval estimates of the shares, and the Z-criterion for the difference of two shares. As the outcomes, the terms and methods of delivery available to the patient group under consideration, as well as the diagnoses of children at the stage of the maternity hospital were selected. To assess the strength of the relationship, Cramer’s V is applied. The result of the analysis is the identification of 56 significant factors and 35 significant correlations, which will be taken into account in the future for the development of the regression model.

Keywords: correlation analysis, p-value, analysis of small data, assisted reproductive technologies, Cramer’s V, Chi-square test, Fisher’s exact test, mathematical statisticscorrelation analysis, p-value, analysis of small data, assisted reproductive technologies, Cramer’s V, Chi-square test, Fisher’s exact test, mathematical statistics.

Full text:
SinotovaSoavtors_1_20_1.pdf

MODELING OF THE PROCESS OF INTERMOLECULAR INTERACTION FOR THE SELECTION OF ANTIDOTES NEUTRALIZING THE TOXIC IMPACT ON THE COMPONENTS OF THE CELLULAR MEMBRANE


UDC 501, 004.942, 615.91
DOI:10.26102/2310-6018/2020.28.1.028

I.M. Azhmukhamedov, L.I. Zharkikh

To study the effects of toxicants on a living organism and the selection of effective antidotes, studies are usually carried out in vivo or at least in vitro, which is a very laborious and costly process. In addition, such studies are not always possible because of ethical considerations. Experiments on living creatures in the most countries are very strictly regulated by law. To eliminate or at least drastically reduce the number of in vivo experiments, it is necessary to use a special apparatus of mathematical modeling. Based on this, the mathematical modeling’s technique of the intermolecular interactions process of cell membrane molecules with toxicants and antidotes to them is proposed in the paper. The main idea of the work is to study the formation’s process of stable bonds of toxicants’ molecules and antidotes with molecules of the cell membrane components , by identifying the active centers of this interaction. It uses specially created algorithms for constructing the structure of a conglomerate of two molecules, analysis and evaluation of the formation of a hydrogen bond between them. For this purpose, systems analysis, quantum chemical calculations, and modular programming are used to calculate the properties of individual molecules and the conglomerate as a whole. All received information is stored in specially designed databases. For a more visual presentation of the results, an original scheme for displaying the signatures of blocked active centers of the cell membrane for the antidotes in question has been proposed. The method of computer modeling outlined in the article allows a targeted search for antidotes to a given toxicant by creating a list ranked by the degree of effectiveness of antidotes.

Keywords: active centers of intermolecular interaction, the signature of the active centers of the components of the cell membrane, identification of the cell membrane of various organs of living organisms, active centers of toxic effects blocked by the antidote.

Full text:
AzhmukhamedovZharkikh_1_20_1.pdf

THE PORTAL REMOTE REHABILITATION “NEURODOM”: IMPLEMENTATION AND TESTING


UDC 378.146 +004.031.42
DOI:10.26102/2310-6018/2020.28.1.017

T.N. Ivanilova, V.A. Semenov, I.V. Vasilenko, M.A. Dneprovskayay, S.Z. Mirbadiev, Y.A. Yurinsky, S.V. Prokopenko, S.A. Subocheva

Remote neurorehabilitation refers to the field of telemedicine and allows the restoration of impaired body functions as a result of spinal injuries, traumatic brain injuries, stroke, heart attack, multiple sclerosis, etc. at the third stage of medical rehabilitation. The portal is designed to create continuous rehabilitation at home with feedback from the doctor; timely adjustment of the individual trajectory of patient rehabilitation; monitoring the results of rehabilitation through online monitoring of the patient’s health using the video recording function built into the system. Performing a set of exercises with the help of information and communication technologies in a remote format will optimally increase the physical, mental and social potential of the patient, for better integration into society. The article describes and presents the results of testing the portal of remote neurorehabilitation: safety testing, functional testing for the roles (doctor, patient, administrator) of the site was checked using test cases; performance testing; for usability – testing, a survey was conducted on real patients and a percentage ratio was compiled; testing the mobile version using the adaptivator tool, which revealed the pros and cons of the mobile version. Testing of the portal was carried out on 20 real patients. Identified errors during testing of the remote portal are resolved. The portal is at the stage of implementation at the Professor Clinic of KrasGMU named after Professors V.F. War-Yasenetsky.

Keywords: remote neurorehabilitation, telemedicine, information system, site testing process, test case.

Full text:
IvanilovaSoavtors_1_20_1.pdf

DIAGNOSIS OF EARLY STAGES OF ATTENTION DISORDERS BASED ON HYBRID FUZZY DECISION RULES

UDC 615.47
DOI:10.26102/2310-6018/2019.27.4.031

A.V. Polyakov, S.N. Rodionova, N.L. Korzhuk, L.V. Starodubtseva


The work is devoted to improving the quality of differential diagnosis of early stages of cognitive impairment in terms of fuzzy description of the studied classes of States.To assess the functions of attention, a device developed at the Department of biomedical engineering of SUSU is used to determine such properties of attention as concentration, volume, selectivity, switchability, distributability and stability. As a mathematical apparatus is used, the hybrid methodology for the synthesis of fuzzy decision rules. The basic element of which is the function of belonging to the studied classes of States (norm, mild cognitive impairment, moderate cognitive impairment, initial clinical stage) with a basic variable determined by the scales of the selected properties of attention.The decision on classification is made by the maximum value of the analyzed membership functions.The obtained mathematical models allow to diagnose the early stages of violations of all the studied functions of attention. Expert confidence in the obtained mathematical models exceeds 0.8. If, together with the level of attention, additional indicators characterizing the functional reserve, levels of psycho-emotional stress and fatigue and energy imbalance of the Meridian structures of the body are used, confidence in the correct classification of the early stages of attention disorders reaches a value of 0.9, which allows us to recommend the results in practical psychology and medicine.

Keywords: the early stage of cognitive impairment of attention, and hybrid decision rules, membership functions, confidence in the correct classification.

Full text:
PolyakovSoavtors_4_19_1.pdf

STUDY ON METHOD FOR MANAGING LOCATION AND PARAMETERS OF FOCAL SPOT FOR NON-INVASIVE SURGERY

UDC 534.222
DOI:10.26102/2310-6018/2019.27.4.007

E.G. Dombrugova, N.N. Chernov


The paper is dedicated to approbation of method for managing location and parameters of focal spot by changing physical characteristics of matching layer. A method is proposed for determining the speed of sound in matching layer for adjusting focal spot by calculating layer thickness-averaged speed of sound in biological tissues on the path of ultrasonic waves. A description of the experimental setup and research methodology is given. The influence of changes in the physical parameters of the matching layer on the distribution of the pressure amplitude in the frontal section of the acoustic field generated by the ultrasonic emitter when the angle of its inclination to the interface varies is estimated. The experimental data are compared with the results of mathematical modeling performed with the same input parameters. The results of calculations of the acoustic field generated by a focusing antenna array in a layered inhomogeneous medium (simulation layers) are presented and the influence of changes in the physical characteristics of the matching layer on the spatial distribution of the acoustic pressure amplitude in the focal region is estimated. The study results showed the possibility of using a matching layer with calculated parameters to control the location of the focal spot in the direction of ultrasonic waves propagation. The developed method for correcting the location of the focal spot can be used both for antenna arrays and for single emitters having the shape of a spherical segment.

Keywords: layer thickness averaged speed of sound, experimental setup, focused ultrasound, matching layer, refraction of ultrasonic waves.

Full text:
DombrugovaChernov_4_19_1.pdf

AUTOMATIC CONTROL OF A CONTINUOUS ROBOT USING THE FABRIK ALGORITHM

UDC 621.865.8
DOI:10.26102/2310-6018/2019.27.4.004

V.V. Danilov, D.Y. Kolpashchikov, N.V. Laptev


Nowadays transcatheter minimally invasive surgery has gained popularity due to the shorter rehabilitation period of patients and lower risks during such interventions. However, this type of surgery is manually performed by surgeons and clinicians, which requires a high skill of specialists. Additionally, transcatheter surgery takes a lot of time and thereby increases the risk of medical error. The robotic solutions available today are expensive and inaccessible to most hospitals, clinics and medical centers. A solution of this problem may be the development of a simple automated control system, the usage of which will increase accuracy, repeatability, and reduce the risks related to the human factor. A medical catheter represents a manipulator that can bend in any point of its structure. This structural feature allows these manipulators to work in places with complex geometry, including the anatomical structures of the human body. In this regard, catheters have found their application in many fields, including medicine and industry. However, the control of this type of robots is complicated by the presence of flexible links tending to infinity. For positioning and orientation of continuous robots, forward and inverse kinematics algorithms are used. One of the most promising approaches is the Forward And Backward Reaching Inverse Kinematics algorithm (FABRIK). In this regard, this paper presents a fast and reliable system without feedback and based on the FABRIK algorithm for automatic control of a continuous robot.

Keywords: continuous robot, catheter, automation, positioning, FABRIK.

Full text:
DanilovSoavtors_4_19_1.pdf

METHOD OF DIFFERENTIAL DIAGNOSTICS OF THE NOSOLOGICAL FORM OF VIRAL HEPATITIS WITH THE APPLICATION OF NEURAL NETWORK OF CASCADE CORRELATION

UDC 004.891.3
DOI:10.26102/2310-6018/2019.26.3.028

A.N. Astafev


An important aspect of determining the nosological form of hepatitis is the combination of input data at the beginning of the study. The use of neural networks in medicine, which have the ability to search for hidden dependencies by learning from the experience of doctors, makes it easier to work in the role of advisor. However, the question of selecting the most effective topology for a specific task remains open. This paper substantiates the need to use neural network algorithms to solve the problem of determining the nosological form of hepatitis. The analysis and selection of input factors characterizing the clinical condition of the patient, and output factors characterizing the specific nosological form of hepatitis, neural network. The algorithm, its use is described, and a cascade neural network is compared with others in the context of the problem under consideration. At the end, a description is made of the established system for determining the nosological form of hepatitis using a cascade correlation neural network, and also describes the clinical efficacy.

Keywords: neural network, viral hepatitis, nosological form of hepatitis, neural network of cascade correlation, classification.

Full text:
Astafev_3_19_1.pdf

INFORMATION-MEASUREMENT SYSTEM FOR RESEARCH OF KINEMATICS OF MOVEMENTS OF THE LOWER LIMBS OF THE PERSON AND WIRELESS DATA TRANSFER

UDC 681.2.089
DOI:10.26102/2310-6018/2019.26.3.011

A.V. Tsareva, A.Y. Kurochkin, V.V.Alekseev


Currently, in medical rehabilitation there are no mobile measuring instruments with software and algorithmic software necessary to control the recovery of the patient in the postoperative period. The existing video systems of motion kinematics control have a high cost and dimensions, so that the acquisition of such a system by medical institutions is difficult. The article describes the information-measuring system for assessing the technique of human walking, consisting of sensors attached to the body and a program on a personal computer that processes the values obtained from the sensors. In the course of work on the creation of this system, rules for selecting the transmission frequency for the measuring channels required for the identification of the step phases using micromechanical sensors have been developed. The spectral characteristics of the accelerometer sensor for each axis of orientation, respectively, are given. The variants of the server implementation when exchanging information via TCP IP Protocol are considered. The software of the server of the distributed information-measuring system is developed. Experimental data of information transfer for each variant of information exchange on the TCP IP Protocol are given. The solution for obtaining the required transmission frequency is described. This system provides for the possibility of use at home, which will help the doctor, the methodist and the patient to monitor the rehabilitation process both during hospital stay and after discharge.

Keywords: biomechanics, medical rehabilitation, kinematic portrait of a person, walking technique, transfer of measuring information

Full text:
TsarevaSoavtori_3_19_1.pdf